The Prognostic Power of Preablation Stimulated Thyroglobulin in Children With Differentiated Thyroid Cancer
Authors' conclusion
The psTg level was the only significant predictor of distant metastases in children with DTC, and psTg ≥ 13.75 ng/mL was the most powerful predictor of first-year incomplete response.
Study context
- Population
- Children (≤18 years) with differentiated thyroid carcinoma (DTC) treated with near-total thyroidectomy, RAI and thyroid hormone replacement at a single centre over 27 years
- Participants
- 126 children
- Exposure
- Preablation stimulated thyroglobulin (psTg) in first-year incomplete response vs others
- Outcome
- Prognostic factors; response to treatment per ATA guidelines
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
psTg level
P = 0.001
Observational data: associations, not effects.
Further findings
Disease characteristics and treatment
- PTC
- 93.7%
- Lymph node metastasis at presentation
- 52.4%
- Extensive (>5) lymph node metastasis
- 30%
- Distant metastasis
- 8.8%
- Mean initial I-131 dose
- 74 ± 42.2 MBq/kg
- Median follow-up
- 59 months
- Median time to excellent response
- 29 months
Sex differences
- Distant metastasis more common in boys than girls; boys took longer to achieve excellent response
Original publication
The Prognostic Power of Preablation Stimulated Thyroglobulin in Children With Differentiated Thyroid Cancer. Endocr Pract. Published 12 December 2023. doi:10.
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