A Pilot Nonrandomized Controlled Trial Examining the Use of Artificial Tears on the Radioactivity of Tears After Radioactive Iodine Treatment for Thyroid Cancer
Authors' conclusion
131I is present in the tears following RAI therapy for thyroid carcinoma. Frequent PFATs starting on the day of RAI ingestion may decrease the level of 131I in the tears.
Study context
- Population
- Contact-lens wearing patients undergoing radioactive iodine (RAI) therapy for papillary thyroid cancer (average 145.7 mCi, range 108–159, of 131I)16 eyes
- Participants
- 8 participants
- Exposure
- Preservative-free artificial tears in right eye vs untreated left eye
- Outcome
- 131I activity in tears (contact lenses), experimental vs control eyes
Methodological detailspilot, prospective, within-patient control (left eye)
- Pilot
- Prospective
- Within-patient control (left eye)
Main finding
As reported in the abstract
Geometric mean 131I activity · day 1
- Geometric mean 131I activity decreased by 26% with preservative free artificial tears (PFATs)
- PFATs vs Control: P = 0.008
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Geometric mean AUC of 131I activity · over four daysPFATs vs Control · decreased by 23% | P = 0.002 |
Geometric mean AUC of 131I activity · over four days
- Geometric mean AUC decreased by 23% with PFATs
Original publication
A Pilot Nonrandomized Controlled Trial Examining the Use of Artificial Tears on the Radioactivity of Tears After Radioactive Iodine Treatment for Thyroid Cancer. Thyroid. Published 11 December 2023. doi:10.
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