Association Between a History of Breast Cancer and Decreased Thyroid Cancer-specific Mortality
Authors' conclusion
This study demonstrates a robust protective effect of a history of BC on TC-specific patient survival, which has strong implications for more precise prognostication of TC in such patients.
Study context
- Population
- Patients with PTC (5598) and follicular thyroid cancer (FTC) (604) with a history of breast cancer (BC) and matched thyroid cancer (TC) patients without BC, Surveillance, Epidemiology and End Results (SEER) 18matched cohort
- Exposure
- TC with history of BC vs matched TC without history of BC
- Outcome
- TC-specific mortality
Methodological detailspropensity-score matched, comparative cohort, SEER 18
- Propensity-score matched
- Comparative cohort
- SEER 18
Main finding
As reported in the abstract
TC-BC vs TCnoBCHazard ratio (95% CI)P value
PTC
0.472(0.370–0.601)
all P < .05FTC
0.656(0.461–0.934)
all P < .05- TC-specific mortality rate, PTC: TC-BC vs TCnoBC
- 1.3% vs 2.6%
- TC-specific mortality rate, FTC: TC-BC vs TCnoBC
- 5.8% vs 8.4%
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| TC-specific mortality in PTC by sequence of cancersTC-BCvs TCnoBCTC occurred before BC | 0.397 (0.268–0.588) | P < 0.001 | |
| TC-specific mortality in PTC by sequence of cancersTC-BCvs TCnoBCBC occurred before TC | 0.607 (0.445–0.827) | P = 0.002 | |
| 0.20.5125Hazard ratio (log scale) |
TC distant metastasis rate
- PTC: TC-BC vs TCnoBC
- 2.4% vs 3.0%
- FTC: TC-BC vs TCnoBC
- 6.1% vs 9.1%
- All P < .05
Original publication
Association Between a History of Breast Cancer and Decreased Thyroid Cancer-specific Mortality. J Clin Endocrinol Metab. Published 8 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →