Characterizing Genetic Alterations Related to Radioiodine Avidity in Metastatic Thyroid Cancer
Authors' conclusion
Patients with the I-RAIR pattern predominantly featured mutations of the BRAF and/or TERT promoter, of which RAS mutations were usually accompanied by late-hit mutations, while fusions mostly occurred alone.
Study context
- Population
- Patients with differentiated thyroid cancer (DTC) with distant metastasis (DM-DTC)
- Participants
- 214 patients
- Exposure
- Initially RAI refractory (I-RAIR) vs initially RAI avid (I-RAIA) patterns by molecular features
- Outcome
- Late-hit mutation (TERT, TP53 or PIK3CA)
Main finding
As reported in the abstract
P = 0.001
- Isolated RET fusions in I-RAIR
- 10%
Observational data: associations, not effects.
Further findings
Rate of I-RAIR pattern by driver gene group — BRAFV600E mutated vs RAS mutated
P < 0.001
| Outcome | P value |
|---|---|
| Rate of I-RAIR pattern by driver gene groupBRAFV600E mutated vs Fusions | P < 0.001 |
Continually RAIA (C-RAIA) pattern within I-RAIA subgroups
- BRAFV600E-mutated tumors have lower prevalence of C-RAIA than RAS-mutated or fusion tumors
Original publication
Characterizing Genetic Alterations Related to Radioiodine Avidity in Metastatic Thyroid Cancer. J Clin Endocrinol Metab. Published 7 December 2023. doi:10.
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