Incidence and gender difference of brain metastases in newly diagnosed follicular thyroid cancer patients
Authors' conclusion
An incidence of brain metastases is observed in newly diagnosed FTC patients with DMs, especially in females with bone involvement. Our findings advocate for the early detection of brain metastases in female FTC patients with concurrent bone metastases at diagnosis.
Study context
- Population
- Patients diagnosed with follicular thyroid cancer (FTC) 2010–2019, SEER database
- Participants
- 5,116 patients
- Exposure
- Female vs male FTC patients
- Outcome
- Incidence of brain metastases at diagnosis
- Follow-up
- Initial diagnosis
Methodological detailsSEER database
- SEER database
Main finding
As reported in the abstract
Brain metastases at initial diagnosis
- Incidence of brain metastases, entire cohort
- 0.37%
- Brain metastases in females
- 17
- Brain metastases in males
- 2
- Brain metastases among patients with bone metastases
- 8.2%
- Brain metastases among patients with lung metastases
- 6.1%
Observational data: associations, not effects.
Further findings
| Outcome | Female | Male | OR (95% CI) | |
|---|---|---|---|---|
| Brain metastases in patients with bone metastases, by gender · diagnosisUnivariate analysis | 12.0% | 1.5% | 8.971 (1.152–69.835) | |
| Brain metastases in patients with bone metastases, by gender · diagnosis | 10.08 (1.243–81.748) | |||
| 0.050.21520Odds ratio (log scale) |
- Brain metastases in patients with bone metastases, by gender: multivariate logistic regression; female sole significant risk factor
Distant metastases (DMs) at diagnosis
- Any DMs
- 4.8% (245)
- Bone metastases
- 3.6%
- Lung metastases
- 2.4%
Median survival with brain metastases
- Median survival
- 8.0 months (95% CI, 4.1-11.9)
Original publication
Incidence and gender difference of brain metastases in newly diagnosed follicular thyroid cancer patients. Eur Thyroid J. Published 12 November 2024. doi:10.
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