Risk-adapted therapy in pediatric thyroid cancer: initial experience from a national reference program by the Malignant Endocrine Tumor (MET) group
Authors' conclusion
The national reference program has successfully introduced a structured, individualized approach to the management of pedDTC in Germany. Ongoing data collection and longer follow-up will be essential to assess the long-term impact of this centralized, risk-adapted model.
Study context
- Population
- Children with confirmed or suspected pediatric DTC referred to the pediatric national reference program of the German MET registry; program's first 3.5 years43 inquiries
- Participants
- 39 children
- Outcome
- Therapeutic decisions in confirmed pediatric differentiated thyroid carcinoma (pedDTC)
Methodological detailsnational expert tumor board, registry-based, Weekly national expert tumor board gave individualized recommendations based on multidisciplinary input and risk stratification
- National expert tumor board
- Registry-based
- Weekly national expert tumor board gave individualized recommendations based on multidisciplinary input and risk stratification
Main finding
As reported in the abstract
Radioactive iodine (RAI) use reduced or omitted, particularly in low-risk patients, in line with ATA 2015 guidelines
70.6%
Surgical strategies modified
61.5%
Observational data: associations, not effects.
Further findings
Short-term outcomes · mean follow-up 0.7 years
- Persistent disease
- 15.4%
- All patients alive
Original publication
Risk-adapted therapy in pediatric thyroid cancer: initial experience from a national reference program by the MET group. Eur Thyroid J. Published 28 July 2025. doi:10.
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