Differentiated thyroid cancer in two European referral centres: impact of different diagnostic and therapeutic strategies
Authors' conclusion
Data reported in the present comparison between two European countries highlight a different prevalence, presentation, and outcome of DTC, likely due to variabilities in healthcare systems, iodine nutritional status, and diagnostic and treatment approaches.
Study context
- Population
- Patients with differentiated thyroid cancer (DTC) at an Italian and a Dutch referral centre
- Participants
- 919 patients
- Exposure
- Italian vs Dutch referral centre cohorts
- Italiann = 586reference
- Dutchn = 333
- Outcome
- Presentation, diagnostic/therapeutic approaches and outcome of DTC
Methodological detailstwo referral centres (Italian and Dutch)
- Two referral centres (Italian and Dutch)
Main finding
As reported in the abstract
- Differences in clinicopathological features and diagnostic/therapeutic modalities
- P < 0.001
Observational data: associations, not effects.
Further findings
TC-related mortality
Dynamic risk stratification (DRS) response
- Dutch cohort: lower rate of indeterminate and higher rate of structural incomplete responses
- P < 0.001
- Comparable excellent and biochemical incomplete responses
5-year progression-free survival (PFS)
- Significantly worse 5-year PFS in Dutch cohort
TC-related mortality
- Disease-specific survival (DSS) still excellent for both
Original publication
Differentiated thyroid cancer in two European referral centres: impact of different diagnostic and therapeutic strategies. Eur Thyroid J. Published 25 July 2025. doi:10.
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