Trends in Survival and Factors Associated with Survival in Primary Thyroid Lymphoma: A SEER-Based Analysis (1975–2021)
Authors' conclusion
PTL survival has significantly improved in recent decades, which may reflect both advances in treatment, particularly the combined use of chemotherapy and radiation, and shifts in disease presentation, including earlier diagnosis and changes in stage distribution.
Study context
- Population
- Adults aged ≥20 years with primary thyroid lymphoma (PTL), diagnosed 1975–2021, SEER; median age 67 years, 69.9% female, 88.8% White; DLBCL 62.5%
- Participants
- 2,465 adults
- Outcome
- Overall survival (OS) and disease-specific survival (DSS) over time, and factors associated with survival
Methodological detailsSEER database, population-based
- SEER database
- Population-based
Main finding
As reported in the abstract
Overall survival and disease-specific survival · median follow-up 83 months (IQR: 24-156)
- Median overall survival (OS)
- 150 months
- 1-year OS
- 84.9%
- 5-year OS
- 72.9%
- 10-year OS
- 57.7%
- 1-year disease-specific survival (DSS)
- 89.1%
- 5-year DSS
- 83.7%
- 10-year DSS
- 80.5%
- Survival significantly improved for patients diagnosed after 2000
- p < 0.001
Observational data: associations, not effects.
Further findings
10-year DSS by treatment
Factors associated with poorer DSS (Cox)
- Age ≥70 years, HR 5.77 (CI 2.71-12.32)
- P < 0.001
- Regional metastatic disease, HR 1.45 (CI 1.04-2.02)
- P = 0.03
- Distant metastatic disease, HR 1.53 (CI 1.17-1.99)
- P = 0.002
Original publication
Trends in Survival and Factors Associated with Survival in Primary Thyroid Lymphoma: A SEER-Based Analysis (1975–2021). Thyroid. Published 30 July 2025. doi:10.
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