Clinical and immunological characteristics of children diagnosed with—Type 1 diabetes during the COVID‐19 pandemic
Authors' conclusion
Our findings suggest that SARS-CoV-2 and the environmental alterations caused by the pandemic affected the clinical characteristics and the immunological profile of children diagnosed with T1D. It is, therefore, plausible that the virus plays a role in the autoimmune process causing T1D.
Study context
- Population
- Children newly diagnosed with T1Dtotal printed as 376
- Participants
- 246 vs 132
- Exposure
- Children diagnosed with T1D during the first 2 years of the COVID-19 pandemic vs the year before
- COVID-19n = 246
- Pre-COVID-19n = 132reference
- Outcome
- Clinical and immunological characteristics at diagnosis
- Follow-up
- At diagnosis
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- pH in children with DKA lower in COVID-19 vs pre-COVID-19 (7.30 [7.18, 7.35] vs 7.33 [7.19, 7.36])
- p = 0.046
- HbA1c tended to be higher in COVID-19 vs pre-COVID-19 (110.9 [86.9, 129.5] vs 100 [80.3, 129.5])
- p = 0.067
- Multiple islet antibodies more common in pre-COVID-19 vs COVID-19 (72% vs 61%)
- p = 0.032
- Tissue transglutaminase antibodies more common in COVID-19 vs pre-COVID-19 (16.6% vs 7.9%)
- p = 0.022
Observational data: associations, not effects.
Original publication
Clinical and immunological characteristics of children diagnosed with—Type 1 diabetes during the COVID‐19 pandemic. Diabet Med. Published 14 November 2023. doi:10.
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