High Rate of Islets Autoimmunity in Pediatric Patients with Index Admission of Acute Pancreatitis
Authors' conclusion
Islet cell autoimmunity is more common in children after their index acute pancreatitis attack (29%) than in the general population (7%-8%). While the frequency of prediabetes and diabetes postacute pancreatitis is high, other mechanisms besides islet cell autoimmunity are responsible.
Study context
- Population
- Children with first episode (index admission) of acute pancreatitis; median age 14 years (IQR 8.7–16.3), 54% female71 with glucose measures
- Participants
- 84 children
- Outcome
- Frequency of islet cell autoimmunity and abnormal glucose testing (prediabetes or diabetes, ADA criteria)
- Follow-up
- Year following index acute pancreatitis
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
As reported in the abstract
Positive for ≥1 of 4 islet cell autoantibodies (IAA, GADA, IA-2A, ZnT8A)
24
29%
≥2 positive islet cell autoantibodies
6
7%
Abnormal glucose testing at or after acute pancreatitis diagnosis
19 of 71
27%
Observational data: associations, not effects.
Further findings
Severe acute pancreatitis, abnormal vs normal glucose testing
P = 0:04
Positive for ≥1 islet cell autoantibody, normal vs abnormal glucose testing
P = 0:004
Original publication
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