Diabetes-Related Quality of Life Assessment in Children following Total Pancreatectomy with Islet Autotransplantation
Authors' conclusion
In youth who underwent TPIAT, DR-QOL worsened over the first two years, mostly attributable to the diabetes symptoms score. Compared to children with T1D, post-TPIAT DR-QOL was similar two years after diabetes onset.
Study context
- Population
- Youth (<20 years old) who underwent total pancreatectomy with islet autotransplantation (TPIAT) for acute recurrent or chronic pancreatitisTPIAT youth
- Participants
- 46 participants
- Exposure
- Youth post-TPIAT vs youth with new-onset T1D
- TPIATn = 46
- Outcome
- Diabetes-related quality of life (PedsQL™ 3.2 Diabetes Module scores)
Methodological detailsdemographically similar (age and sex)
- Demographically similar (age and sex)
Main finding
As reported in the abstract
PedsQL™ DM scores over time post-TPIAT · first 24 months post-TPIAT
- Diabetes symptoms summary score decreased (worsened), mean 65 to 57; met MCID threshold
- p=0.03
- Total score decreased (worsened), mean 74 to 68; met MCID threshold
- p < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| PedsQL™ DM scores, TPIAT vs T1D · 24 monthsNot significantly different | all p > 0.2 |
- PedsQL™ DM scores, TPIAT vs T1D: TPIAT n = 29 at 12 months, n = 16 at 24 months; T1D n = 52 at 12 months, n = 58 at 24 months
Original publication
Diabetes-Related Quality of Life Assessment in Children following Total Pancreatectomy with Islet Autotransplantation. Pediatr Diabetes. Published 22 June 2023. doi:10.
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