Follow-Up of Patients After Total Pancreatectomy and Islet Cell Autotransplantation at Off-Site Islet Isolation Facility
Authors' conclusion
Our long-term follow-up data suggest that IAT can effectively reduce insulin requirements and improve postoperative glycemic control.
Study context
- Population
- Patients with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation (TPIAT) with an off-site islet isolation facility; median age 46.0 years (range 20–78)
- Participants
- 44 patients
- Exposure
- Insulin independent vs Insulin dependent
- Insulin independentn = 8
- Insulin dependentn = 36
- Outcome
- Efficacy of TPIAT: insulin independence
- Follow-up
- Up to 12 years
Methodological detailssingle-group follow-up, off-site islet isolation facility
- Single-group follow-up
- Off-site islet isolation facility
Main finding
As reported in the abstract
Insulin independence · median follow-up 845.5 days (range 195-4470)
Insulin independent
8
events
Insulin dependent
36
events
Observational data: associations, not effects.
Further findings
HOMA-IR · most recent follow-up
- HOMA-IR comparable between insulin independent and dependent cohorts
Original publication
Follow-Up of Patients After Total Pancreatectomy and Islet Cell Autotransplantation at Off-Site Islet Isolation Facility. J Clin Endocrinol Metab. Published 13 December 2022. doi:10.
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