SARS-CoV-2 and type 1 diabetes in children in Finland: an observational study
Main finding · T1D incidence, children <15 yearsResult — go to the resultIRR adjusted for age and sex 1.16 CI 1.06–1.25Authors' conclusion
Children and adolescents diagnosed with type 1 diabetes during the pandemic had a more severe disease at diagnosis. The observed increase in type 1 diabetes incidence during the first 18 months could be a consequence of lockdown and physical distancing rather than a direct effect of SARS-CoV-2 infection.
Study context
- Population
- Children in Finland younger than 15 years with newly diagnosed T1D; confirmed monogenic diabetes excluded
- Participants
- 785 vs 2,096
- Exposure
- First 18 months of COVID-19 pandemic vs pre-pandemic reference period
- Pandemicn = 785
- Reference periodn = 2,096reference
- Outcome
- Incidence of T1D (newly diagnosed per 100 000 person-years)
- Follow-up
- First 18 months of the COVID-19 pandemic
Methodological detailsregistry-based (Finnish Pediatric Diabetes Register)
- Registry-based (Finnish Pediatric Diabetes Register)
Main finding
T1D incidence, children <15 years
IRR adjusted for age and sex
1.16
CI 1.06–1.25
P = 0.0006
By group
Pandemic
61.0 per 100 000 person-years
CI 56.8–65.4
Reference period
52.3 per 100 000 person-years
CI 50.1–54.6
Pandemicvs Reference period
IRR adjusted for age and sex 1.16 (CI 1.06–1.25); P = 0.0006
As reported in the abstract
Observational data: associations, not effects.
Further findings
- Phenotype at diagnosis
- P < 0.001
- Phenotype at diagnosis
- P < 0.001
- Phenotype at diagnosis
- P < 0.001
- Infection-induced SARS-CoV-2 antibodies among pandemic-period diagnoses
- 0.9% · 5
- Infection-induced SARS-CoV-2 antibodies among pandemic-period diagnoses: 583 tested
HLA genotype distribution
- No significant differences in HLA genotype distribution between the two periods
Original publication
SARS-CoV-2 and type 1 diabetes in children in Finland: an observational study. Lancet Diabetes Endocrinol. Published April 2023. doi:10.
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