SARS‐CoV‐2 infection and new‐onset type 1 diabetes in the post‐acute period among children and young people in England
Authors' conclusion
SARS-CoV-2 infection is associated with subsequent incident type 1 diabetes in the 1-7 months after an acute infection in previously healthy CYP.
Study context
- Population
- Children and young people (CYP) aged 0–17 in England, all hospital activity data; CYP with prior chronic illnesses excluded
- Participants
- 1,087,604 / 143,748 / 253,368 / 160,925 / 388,673
- Exposure
- SARS-CoV-2 exposed vs unexposed CYP
- Exposedn = 1,087,604
- Trauman = 143,748reference
- Electiven = 253,368reference
- Historic trauman = 160,925reference
- Historic electiven = 388,673reference
- Outcome
- New-onset T1D
- Follow-up
- From day 28 after a positive test for the following 6 months
Methodological detailsCox regression adjusted for age, sex, ethnicity, deprivation and season of index date, stratified by variant-dominant periods
- Cox regression adjusted for age, sex, ethnicity, deprivation and season of index date
- Stratified by variant-dominant periods
Main finding
As reported in the abstract
Hazard of developing T1D · day 28 to 6 months after positive test
Hazard ratio (CI)
Exposedvs Trauma
2.4(1.58–3.64)
Exposedvs Elective
2.9(2.00–4.13)
Exposedvs Historic trauma
4.2(2.56–7.04)
Exposedvs Historic elective
2.4(1.81–3.10)
Observational data: associations, not effects.
Further findings
Association by variant period
- Associations may be strongest during the Delta period
Original publication
SARS‐CoV‐2 infection and new‐onset type 1 diabetes in the post‐acute period among children and young people in England. Diabet Med. Published 17 June 2025. doi:10.
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