Association of COVID-19 and Development of Type 1 Diabetes: A Danish Nationwide Register Study
Authors' conclusion
There was an increase in T1D incidence during April-June 2021 compared with April-June 2015-2019, but this could not be attributed to SARS-CoV-2 infection.
Study context
- Population
- All Danish residents aged <30 years free of diabetes, 2015–20213,579 T1D cases
- Participants
- 2,381,348 residents
- Exposure
- T1D incidence during COVID-19 pandemic (2020–2021) vs 2015–2019; SARS-CoV-2 infection vs no infection
- SARS-CoV-2 positiven = 338,670
- Controlsn = 1,004,688reference
- Outcome
- Incidence of T1D
Methodological detailsmatched cohort (3 controls per infected individual), Poisson regression, cause-specific Cox regression
- Matched cohort (3 controls per infected individual)
- Poisson regression
- Cause-specific Cox regression
Main finding
As reported in the abstract
T1D incidence, each quarter of 2020 and 2021 vs 2015-2019
Adjusted incidence rate ratio (95% CI)
January-March 2020vs 2015-2019
1.03(0.86–1.23)
January-March 2021vs 2015-2019
1.01(0.84–1.22)
April-June 2020vs 2015-2019
0.98(0.80–1.20)
April-June 2021vs 2015-2019
1.34(1.12–1.61)
July-September 2020vs 2015-2019
1.13(0.94–1.35)
July-September 2021vs 2015-2019
1.21(1.01–1.45)
October-December 2020vs 2015-2019
1.09(0.91–1.31)
October-December 2021vs 2015-2019
1.18(0.99–1.41)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Risk of T1D development after SARS-CoV-2 infectionNot significantly associated · matched cohort | 0.90 (0.60–1.35) | |
| 0.512Hazard ratio (log scale) |
Original publication
Association of COVID-19 and Development of Type 1 Diabetes: A Danish Nationwide Register Study. Diabetes Care. Published 5 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →