Neuropathy in adolescents with type 1 diabetes: Confirmatory diagnostic tests, bedside tests, and risk factors
An erratum to this article was published (Diabetes Res Clin Pract, Nov 2023 ↗)
Authors' conclusion
The diagnostic tests confirmed the presence of neuropathy in adolescents with diabetes and underscore the importance of prevention and screening.
Study context
- Population
- Adolescents with T1D (diabetes duration > five years); mean HbA1c 7.6% (60 mmol/mol)
- Participants
- 60 vs 23
- Exposure
- Adolescents with T1D vs controls; bedside tests vs confirmatory diagnostic tests
- T1Dn = 60
- Controlsn = 23reference
- Outcome
- Prevalence of large fiber, small fiber and autonomic neuropathy by confirmatory tests
Main finding
As reported in the abstract
Prevalence of neuropathies in adolescents with T1D
- Confirmed LFN
- 14%
- Subclinical LFN
- 26%
- Confirmed SFN
- 2%
- Subclinical SFN
- 25%
- Abnormal quantitative sudomotor axon reflex test (QSART)
- 20%
- Abnormal cardiovascular reflex tests (CARTs)
- 8%
- Orthostatic hypotension
- 14%
Observational data: associations, not effects.
Further findings
Risk factors for neuropathy
- Higher age, higher insulin dose, previous smoking and higher TG level increased the relative risk for neuropathy
Bedside tests (biothesiometry, DPNCheck®, Sudoscan, Vagus®device) vs confirmatory tests
- Poor to acceptable concordance (all)
- AUC ≤ 0.75
- ROC analysis
Original publication
Neuropathy in adolescents with type 1 diabetes: Confirmatory diagnostic tests, bedside tests, and risk factors. Diabetes Res Clin Pract. Published 3 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →