Circulating Long Noncoding RNA Signatures Associate With Incident Diabetes in Older Adults: A Prospective Analysis From the VITA Cohort Study
Authors' conclusion
We found a set of circulating lncRNAs that independently portends incident type 2 diabetes in older adults years before disease onset.
Study context
- Population
- Older adults without diabetes from the Vienna Transdanube Aging study; validation cohort of individuals with and without T2Dvalidation cohort n = 90
- Participants
- 296 adults
- Outcome
- Incident T2D
- Follow-up
- 7.5 years
Methodological detailsvalidation cohort
- Validation cohort
Main finding
As reported in the abstract
7.5-year follow-up
- Four Long noncoding RNAs (lncRNAs) (ANRIL, MIAT, RNCR3, PLUTO) associated with incident T2D and linked to HbA1c trajectories
Observational data: associations, not effects.
Further findings
- Similar results in the validation cohort (for MIAT and PLUTO also in combined analysis)
Original publication
Circulating Long Noncoding RNA Signatures Associate With Incident Diabetes in Older Adults: A Prospective Analysis From the VITA Cohort Study. Diabetes Care. Published 11 April 2023. doi:10.
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