Lymphocytes regulate expression of the SARS‐CoV‐2 cell entry factor ACE2 in the pancreas of T2DM patients
Authors' conclusion
Increased blood glucose levels are associated with increased ACE2 expression and an increased number of lymphocytes. At the same time, lymphocytes can promote ACE2 expression.
Study context
- Population
- Clinical pancreatic samples of T2D patients and diabetic mouse models
- Outcome
- ACE2 and TMPRSS2 expression in pancreatic cell types
Methodological detailssingle-cell sequencing, bioinformatics analysis, diabetic mouse models
- Single-cell sequencing
- Bioinformatics analysis
- Diabetic mouse models
Main finding
As reported in the abstract
- ACE2 and TMPRSS2 are expressed in the ducts of the human pancreas
- T2D can promote co-expression of ACE2 and TMPRSS2 in exocrine ducts, including in the human pancreas
- Hypothesis: ACE2 expression levels are associated with increased numbers of lymphocytes in vivo
Original publication
Lymphocytes regulate expression of the SARS‐CoV‐2 cell entry factor ACE2 in the pancreas of T2DM patients. Diabet Med. Published 11 April 2023. doi:10.
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