Multi-omics signatures of circulating factors associated with cardiorespiratory fitness adaptations in individuals with prediabetes
Authors' conclusion
Our findings reveal that baseline proteomic and metagenomic signatures are associated with VO₂peak adaptations.
Study context
- Population
- Medication-naïve, overweight and obese Chinese men with prediabetes, aged 24–62 years
- Participants
- 35 participants
- Outcome
- Change in VO₂peak (ΔVO₂peak) and its association with baseline and exercise-induced circulating proteins, gut microbial composition and metabolites
- Follow-up
- 12 weeks
Methodological detailssingle-group 12-week high-intensity interval training (HIIT) intervention, multi-omics (serum proteomics, fecal metagenomics, targeted metabolomics)
- Single-group 12-week HIIT intervention
- Multi-omics (serum proteomics, fecal metagenomics, targeted metabolomics)
Main finding
As reported in the abstract
Associations with ΔVO₂peak
- Mean VO₂peak increase after 12 weeks of HIIT
- 0.47 L/min
- Range of individual VO₂peak responses
- 0 to 1.7 L/min
- Baseline Prevotella (short-chain fatty acid (SCFA)-producing), positive association
- β = 105.65, P = < 0.001, FDR = 0.034
- Baseline Coprococcus (SCFA-producing), positive association
- β = 50.22, P = 0.01, FDR = 0.39
- Baseline Hungatella (SCFA-producing), positive association
- β = 40.72, P = 0.025, FDR = 0.50
- Baseline erythropoietin (EPO), negative association
- β = −279.03, P = 0.024, FDR = 0.99
- Exercise-induced change in growth hormone 1, positive association
- β = 63.97, P = 0.04, FDR = 0.99
- Exercise-induced change in BTB and CNC Homology 1 (repressor of heme oxygenase-1), negative association
- β = −250.82, P = 0.01, FDR = 0.99
Further findings
Multiple linear regression with clinical variables for ΔVO₂peak
- Percentage lean mass, strongest variable associated with ΔVO₂peak
- β = 64.17, P = 0.0005
- Variance explained by clinical model
- 27%
- Variance explained after adding exercise-associated circulating factors such as EPO
- 37% (P = 0.002)
Original publication
Multi-omics signatures of circulating factors associated with cardiorespiratory fitness adaptations in individuals with prediabetes. Cardiovasc Diabetol. Published 12 July 2026. doi:10.
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