Children with Attention Deficit Hyperactivity Disorder Are More Likely to Fail Growth Hormone Stimulation Testing than Children without Attention Deficit Hyperactivity Disorder: A Retrospective Chart Review
Authors' conclusion
The result shows higher likelihood of lower GH peaks in response to GHST in children with ADHD and short stature or impaired linear growth. Future work should evaluate possible mechanistic explanation and the role of psycho-stimulant medications.
Study context
- Population
- Children who underwent growth hormone stimulation testing (GHST) for short stature and/or growth failure with an intact pituitary, 2002–2018
- Participants
- 260 children
- Exposure
- Children with ADHD vs without ADHD
- ADHDn = 78
- Outcome
- Failure of GHST at peak GH cut-offs of 10, 7 and 5 ng/mL
Methodological detailsretrospective chart review, logistic regression with stratification by age
- Retrospective chart review
- Logistic regression with stratification by age
Main finding
As reported in the abstract
Failed GHST
- Same trend after regression with adjustment for sex and stratification by age; effect more robust in the older group
- ADHD vs Without ADHD: P = 0.003
- ADHD vs Without ADHD: P = 0.023
- ADHD vs Without ADHD: P = 0.046
Observational data: associations, not effects.
Further findings
Age
Z-scores for height, weight, BMI and mid-parental height
- No difference between the two groups
ADHD not medically treated
- Children with ADHD not medically treated
- 9
Original publication
Children with Attention Deficit Hyperactivity Disorder Are More Likely to Fail Growth Hormone Stimulation Testing than Children without Attention Deficit Hyperactivity Disorder: A Retrospective Chart Review. Horm Res Paediatr. Published 11 October 2022. doi:10.
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