The Effect of a Nutritional Supplement on Growth and Body Composition in Short and Lean Preadolescent Boys following One Year of Intervention
Authors' conclusion
An intervention in healthy peripubertal boys suggests that 1-year consumption of a multi-nutrient, protein-rich nutritional supplement is efficacious and safe. The induced changes in growth and body composition, although modest, may be clinically significant. The effect of the formula on growth parameters was not mediated by enhancement of the pubertal tempo.
Study context
- Population
- Short and lean peripubertal boys aged ≥10 years, Tanner stages 1–379 completed extension
- Participants
- 98 participants
- Comparison
- Good vs poor nutritional formula consumers during open-label extension
Methodological detailsopen-label extension of a randomised placebo-controlled trial, 2-phase, 1-6 months double-blinded, placebo-controlled, 6-12 months open-label extension
- Open-label extension of a randomised placebo-controlled trial
- 2-phase
- 1-6 months double-blinded, placebo-controlled
- 6-12 months open-label extension
Primary result
As reported in the abstract
Change in height-SDS · extension phase and 12 months
- Good consumers vs Poor consumers: P = 0.028
- Good consumers vs Poor consumers: P = 0.009
Further findings
Dose-response correlation of formula consumption with Δ height-SDS, Δ weight-SDS and Δ muscle mass · extension phase
- Significant dose-response correlation, crude and adjusted for baseline age and end-of-study Tanner stage
- P < 0.05
Tanner stage
- No between-group differences at any point of the study
Safety
- No serious adverse events were reported
Original publication
The Effect of a Nutritional Supplement on Growth and Body Composition in Short and Lean Preadolescent Boys following One Year of Intervention. Horm Res Paediatr. Published 5 September 2022. doi:10.
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