Pre‐ and peripubertal sex steroids are inversely associated with birth weight in preterm boys
Authors' conclusion
Lower BW was associated with increased sex steroid concentrations from 8 years of age, independently of clinical signs of puberty.
Study context
- Population
- Preterm boys, birth weight (BW) 1325–3320 g, GA 32 + 2 to 36 + 6 weeks, followed at 5–10 years of age
- Participants
- 58 participants
- Outcome
- Association of serum sex steroid concentrations (gas chromatography-tandem mass spectrometry) with BW
- Follow-up
- 5-10 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Correlation of sex steroids with BW
- Testosterone vs BW at 8 years (ρ)
- −0.35, p = .021
- Estrone vs BW at 8 years (ρ)
- −0.34, p = .024
- Testosterone vs BW at 10 years (ρ)
- −0.39, p = .010
- Dihydrotestosterone vs BW at 10 years (ρ)
- −0.38, p = .013
- Estrone vs BW at 10 years (ρ)
- −0.44, p = .003
- Estradiol vs BW at 10 years (ρ)
- −0.36, p = .019
Observational data: associations, not effects.
Further findings
Correlation of weight gain from birth with testosterone
- At 5 years (ρ)
- 0.40, p = .002
- At 7 years (ρ)
- 0.30, p = .040
- At 8 years (ρ)
- 0.44, p = .003
- At 10 years (ρ)
- 0.40, p = .008
Correlation of testosterone with luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testicular volume · 10 years
- Testosterone vs LH (ρ)
- 0.42, p = .006
- Testosterone vs FSH (ρ)
- 0.33, p = .033
- Testosterone not correlated with testicular volume
Original publication
Pre‐ and peripubertal sex steroids are inversely associated with birth weight in preterm boys. Clin Endocrinol (Oxf). Published 29 September 2022. doi:10.
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