Characterizing regional and global effects of epicardial adipose tissue on cardiac systolic and diastolic function
Authors' conclusion
There was no association between regional EAT deposition and corresponding regional LV segment function. Furthermore, the association between total EAT and diastolic function was attenuated after adjustment for visceral fat, indicating that systemic metabolic impairments contribute to diastolic dysfunction in high-risk middle-aged adults.
Study context
- Population
- Patients with obesity with elevated cardiac biomarkers and visceral fat
- Participants
- 71 patients
- Outcome
- Localized effects of regional EAT on adjacent myocardial LV function (regional longitudinal LV strain)
Methodological detailsCardiac magnetic resonance imaging (MRI), echocardiography, DXA and exercise testing; total and regional (anterior, inferior, lateral, right ventricular) epicardial adipose tissue (EAT) quantified by MRI
- Cardiac MRI, echocardiography, DXA and exercise testing; total and regional (anterior, inferior, lateral, right ventricular) EAT quantified by MRI
Main finding
As reported in the abstract
Regional EAT and adjacent regional longitudinal LV strain
- No evidence for localized effects of regional EAT deposition on adjacent regional longitudinal strain
Observational data: associations, not effects.
Further findings
EAT and visceral adiposity
- EAT associated with visceral adiposity (r)
- r = 0.47, p < 0.0001
- EAT not associated with total fat mass
Total EAT and diastolic function (e', E/A, E/e')
- Total EAT associated with e', E/A and E/e'; only E/A remained significant after adjustment for visceral adiposity (r)
- r = −0.30, p = 0.015
- Right ventricular and left ventricular (LV) EAT had similar associations with diastolic function
- Adjusted for visceral adiposity
Original publication
Characterizing regional and global effects of epicardial adipose tissue on cardiac systolic and diastolic function. Obesity (Silver Spring). Published 27 June 2023. doi:10.
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