The effect of weight loss on whole‐body and tissue‐specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy
Authors' conclusion
Weight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight-loss-induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity.
Study context
- Population
- Adults aged 18–65 years with overweight or obesity (BMI ≥ 25 kg/m²)
- Participants
- 50 adults
- Comparison
- After vs before 2-month low-energy diet
- Low-energy diet (LED)n = 50
Methodological detailssingle-group, before–after
- Single-group
- Before–after
Primary result
As reported in the abstract
2 months
- After LED vs Baseline: P < 0.001
- After LED vs Baseline: P < 0.001
- After LED vs Baseline: P = 0.260
Further findings
| Outcome | P value |
|---|---|
| Body weight · after 2-month LEDReduced | P < 0.001 |
| Whole-body insulin sensitivity (Matsuda index) and HIRI · after 2-month LEDMatsuda index increased; HIRI reduced | both p < 0.001 |
| Muscle insulin sensitivity index (MISI) · after 2-month LEDNo change | P = 0.260 |
| IHL content · after 2-month LEDDecreased | P < 0.001 |
| Hepatic saturated fatty acid fraction · after 2-month LEDDecreased | P = 0.039 |
Body weight · after 2-month LED
- The LED reduced body weight
Whole-body insulin sensitivity (Matsuda index) and hepatic insulin resistance index (HIRI) · after 2-month LED
- Increased Matsuda index and reduced HIRI
Muscle insulin sensitivity index (MISI) · after 2-month LED
- No change in MISI
Intrahepatic lipid (IHL) content · after 2-month LED
- Weight loss decreased IHL content
Hepatic saturated fatty acid fraction · after 2-month LED
- Weight loss decreased the hepatic saturated fatty acid fraction
Association of reduced IHL content with improvement in HIRI
- Correlation (r)
- 0.402
- P
- P = 0.025
Original publication
The effect of weight loss on whole‐body and tissue‐specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy. Obesity (Silver Spring). Published 27 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →