Lower abdominal adipose tissue cannabinoid type 1 receptor availability in young men with overweight
Authors' conclusion
The results suggest endocannabinoid dysregulation already in the preobesity state.
Study context
- Population
- Healthy young males with high or low obesity risk
- Participants
- 16 vs 20
- Exposure
- High vs low obesity risk
- HRn = 16
- LRn = 20reference
- Outcome
- CB1R availability in abdominal adipose tissue, brown adipose tissue, muscle and brain
Methodological detailsPET imaging with [18F]FMPEP-d2, hyperinsulinemic-euglycemic clamp with FDG PET
- PET imaging with [18F]FMPEP-d2
- Hyperinsulinemic-euglycemic clamp with FDG PET
Main finding
As reported in the abstract
CB1R availability
- CB1R availability in abdominal adipose tissue was lower in HR than LR
- No difference in other tissues (brown adipose tissue, muscle, brain)
Observational data: associations, not effects.
Further findings
Correlates of CB1R availability
- CB1R availability of abdominal adipose tissue and brain correlated positively with insulin sensitivity and negatively with unfavorable lipid profile, BMI, body adiposity and inflammatory markers
Serum arachidonoyl glycerol
- Associated with lower whole-brain CB1R availability, unfavorable lipid profile and higher serum inflammatory markers
Original publication
Lower abdominal adipose tissue cannabinoid type 1 receptor availability in young men with overweight. Obesity (Silver Spring). Published 27 June 2023. doi:10.
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