Relationships between abdominal adipose tissue and neuroinflammation with diffusion basis spectrum imaging in midlife obesity
Authors' conclusion
The findings suggest that, at midlife, obesity and abdominal fat are associated with reduced brain axonal density and increased inflammation, with visceral fat playing a significant role in both sexes.
Study context
- Population
- Cognitively normal midlife participants; mean age 49.4 (SD 6.2) years; 34 males (34.7%); 56 with obesity (57.1%)
- Participants
- 98 participants
- Exposure
- High vs low BMI, VAT, SAT, insulin resistance, systemic inflammation and Centiloids
- Outcome
- White matter neuroinflammation measures by diffusion basis spectrum imaging
Methodological detailstract-based spatial statistics, age and sex as covariates
- Tract-based spatial statistics
- Age and sex as covariates
Main finding
As reported in the abstract
White matter diffusion basis spectrum imaging measures
- Obesity, high VAT and high SAT linked to lower axial diffusivity, reduced fiber fraction and increased restricted fraction in white matter
- Obesity additionally associated with higher hindered fraction and lower fractional anisotropy
- High C-reactive protein associated with lower axial diffusivity
- Higher restricted fraction correlated with continuous BMI and SAT particularly in males; VAT effects similar in males and females
Observational data: associations, not effects.
Original publication
Relationships between abdominal adipose tissue and neuroinflammation with diffusion basis spectrum imaging in midlife obesity. Obesity (Silver Spring). Published 8 November 2024. doi:10.
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