Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region
Authors' conclusion
Age of obesity onset appears to affect SAT morphology differently in the abdominal and femoral regions of male and female adults. Our findings challenge the notion that SAT is uniformly hyperplastic in CO and hypertrophic in AO.
Study context
- Population
- Male and female adults with childhood-onset (n = 8 males, n = 16 females) or adult-onset obesity (n = 8 males, n = 13 females); abdominal and femoral subcutaneous adipose tissue (SAT) biopsies
- Exposure
- Childhood-onset obesity vs adult-onset obesity
- Outcome
- Abdominal and femoral SAT morphology (degree of adipocyte hyperplasia or hypertrophy), by age of obesity onset and sex
Methodological detailsAdipocytes isolated via collagenase digestion; regional body composition by DXA and single-slice abdominal CT; mean adipocyte size measured
- Adipocytes isolated via collagenase digestion; regional body composition by DXA and single-slice abdominal CT; mean adipocyte size measured
Main finding
As reported in the abstract
- Femoral SAT morphology more hypertrophic in males and females with CO than AO
- CO vs AO: P = 0.004
- CO vs AO: P = 0.996
Observational data: associations, not effects.
Original publication
Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region. Obesity (Silver Spring). Published 24 July 2024. doi:10.
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