Association between thyroid hormone resistance and obesity: a cross‐sectional study and mouse stimulation test
Authors' conclusion
Euthyroid individuals with obesity exhibit both central and peripheral thyroid hormone resistance, a phenomenon that is more pronounced in individuals with metabolic abnormalities. Thyroid hormone resistance is associated with an increased prevalence of overweight and obesity mediated by metabolic disorders.
Study context
- Population
- Euthyroid individuals; plus control and obese mice
- Participants
- 8,021 euthyroid individuals
- Exposure
- Thyroid hormone resistance indices vs overweight and obesity in euthyroid individuals
- Outcome
- Association of thyroid hormone resistance indices with overweight and obesity
Methodological detailsmouse TRH stimulation test
- Mouse TRH stimulation test
Main finding
As reported in the abstract
- Euthyroid adults with overweight and obesity had increased thyroid hormone resistance indices
- all p < 0.05
- Prevalence of overweight and obesity with elevation of TFQI, OR
- 1.164, p = 0.036
- Prevalence of overweight and obesity with elevation of FT3/FT4, OR
- 1.508, p < 0.001
Observational data: associations, not effects.
Further findings
Mediation by metabolic disorders
- Complete mediation effect of metabolic disorders, beta coefficient of indirect effect
- 6.838, p < 0.001
TSH response to TRH stimulation in obese mice (n = 5)
- TSH response comparatively blunted in obese mice (68.33-90.89 pg/mL)
- P = 0.029
Original publication
Association between thyroid hormone resistance and obesity: a cross‐sectional study and mouse stimulation test. Obesity (Silver Spring). Published 24 July 2024. doi:10.
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