Obesity

Combined lifestyle factors and metabolic syndrome risk: a systematic review and meta-analysis

Int J Obes (Lond)Published Systematic review and meta-analysis of cross-sectional and cohort studies

Authors' conclusion

Adherence to a healthy lifestyle pattern was beneficial to metabolic syndrome prevention.

Study context

Population
Cross-sectional and cohort studies of lifestyle scores/indices (top factors: physical activity, diet, smoking) and metabolic syndrome; Embase and Medline19 studies · 16 publications
Comparison
Healthiest vs least-healthy lifestyles
Outcome
Metabolic syndrome risk
Methodological detailsrandom-effects models, multivariable-adjusted estimates, subgroup and sensitivity analyses
  • Random-effects models
  • Multivariable-adjusted estimates
  • Subgroup and sensitivity analyses

Pooled result

As reported in the abstract

Lower metabolic syndrome risk with healthiest vs least-healthy lifestyles

43%

Further pooled results

OutcomeOR (95% CI)
Metabolic syndrome prevalence (subgroup: cross-sectional studies)0.62 (0.51–0.73)
Metabolic syndrome incidence (subgroup: cohort studies)0.40 (0.11–0.68)

Other subgroup and sensitivity analyses

The inverse association was consistent in other subgroup and sensitivity analyses

Original publication

Combined lifestyle factors and metabolic syndrome risk: a systematic review and meta-analysis. Int J Obes (Lond). Published 8 November 2024. doi:10.1038/s41366-024-01671-8

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