Increased epicardial adipose tissue is part of the phenotype of LMNA-associated partial lipodystrophy and could contribute to increased cardiovascular risk
Authors' conclusion
Our findings support that EAT is increased in patients with FPLD2 and represents a specific ectopic adipose tissue which could contribute to the increased cardiovascular risk.
Study context
- Population
- Patients with familial partial lipodystrophy (FPLD2) or T2D with cardiac CT routinely performed for coronary artery calcium scoring
- Participants
- 26 vs 44
- Exposure
- FPLD2 vs T2D
- FPLD2n = 26
- T2Dn = 44reference
- Outcome
- EAT volume
Methodological detailsdeep-learning algorithm epicardial adipose tissue (EAT) measurement on cardiac CT
- Deep-learning algorithm EAT measurement on cardiac CT
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Prevalence of CAD · higher with FPLD2
P = 0.003
HbA1c · lower with FPLD2
P = 0.003
| Outcome | FPLD2 | T2D | P value |
|---|---|---|---|
| BMILower with FPLD2 | 23.3 (IQR 21–26.6) | 27.2 (IQR 24.7–29.6) | P = 0.03 |
EAT vs coronary artery calcium (CAC) score in FPLD2
- EAT was positively related to CAC score in the FPLD2 group
Original publication
Increased epicardial adipose tissue is part of the phenotype of LMNA-associated partial lipodystrophy and could contribute to increased cardiovascular risk. Diabetes Metab. Published 25 October 2025. doi:10.
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