Adiposome Lipidomic Shifts Following Bariatric Surgery in Association With Weight Loss and Cardiometabolic Benefit
Authors' conclusion
Bariatric surgery remodels adiposome lipids, and these shifts align with improvements in cardiometabolic risk markers.
Study context
- Population
- Obese individuals undergoing bariatric surgery; adipose tissue biopsies with adiposome isolation
- Participants
- 23 individuals
- Exposure
- After vs before bariatric surgery
- Outcome
- Adiposome lipidome remodelling
Methodological detailsbefore-and-after, non-targeted lipidomic analysis using mass spectrometry
- Before-and-after
- Non-targeted lipidomic analysis using mass spectrometry
Main finding
As reported in the abstract
Lipid species identified across 19 classes
550
Species increased after surgery
124
Species decreased after surgery
66
Lipid species whose change correlated with body mass index (BMI) change (TG 18:1/20:4/22:6 positively; Sphingomyelins (SM) d40:1, SM d42:4, phosphatidylcholine 17:0/18:2 inversely)
36
Observational data: associations, not effects.
Further findings
Clinical and vascular changes after surgery
- Significant reductions in BMI, visceral fat, HOMA-IR, inflammatory markers and systolic blood pressure, with marked improvements in vascular function
- Improvements in nitric oxide, vascular reactivity and adiponectin tracked with rises in ultralong-chain ceramide/fatty acid-hydroxy fatty acids (FAHFAs)/phospholipids and declines in acylcarnitine/cholesterol esters/diacylglycerols/phosphatidic acids
Machine learning prediction of BMI from lipid features
- Accuracy
- >80%
- R2
- >0.90
- Mean absolute error
- <0.3
- Top contributors: SM d40:1, SM d42:4 and fatty acid 17:1
Pathway enrichment
- Changes linked to sphingolipid signaling and glycerophospholipid metabolism
Original publication
Adiposome Lipidomic Shifts Following Bariatric Surgery in Association With Weight Loss and Cardiometabolic Benefit. J Clin Endocrinol Metab. Published 24 October 2025. doi:10.
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