Lipidomics analysis to assess metabolic complications in familial partial lipodystrophy type 2
Authors' conclusion
Lipidomic analyses reveal different species in control and FPLD2 groups, and the signature for type 2 diabetes coincide with the one for lipoatrophic diabetes. Moreover, the mBMI can be useful to assess metabolic health in FPLD2, especially individuals with normal BMI.
Study context
- Population
- Adults with familial partial lipodystrophy type 2 (LMNA 'Reunionese' variant) and unaffected age and sex matched adults787 lipid species analysed
- Participants
- 115 vs 289
- Comparison
- FPLD2 vs unaffected controls
- FPLD2n = 115
- Controln = 289reference
- Outcome
- Lipid species differing between FPLD2 and control
Methodological detailsage and sex matched controls, liquid chromatography-tandem mass spectrometry
- Age and sex matched controls
- Liquid chromatography-tandem mass spectrometry
Main finding
As reported in the abstract
- Significant lipid species
- 181
- Ceramides, TG, diacylglycerol higher in FPLD2 vs control
- P < 0.05
- Plasmalogen, phosphatidylcholine, sphingolipids lower in FPLD2 vs control
- P < 0.05
Observational data: associations, not effects.
Further findings
T2D lipidomic signature
- T2D lipidomic signature reproduced in controls with T2D and in lipoatrophic diabetes
Metabolic BMI score (mBMI)
- mBMI higher in FPLD2, especially individuals with BMI in the normal range
Original publication
Lipidomics analysis to assess metabolic complications in familial partial lipodystrophy type 2. Diabetes Res Clin Pract. Published 4 May 2026. doi:10.
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