Characteristics of changes in bone mineral density and body composition in obesity patients after metabolic and bariatric surgery: A prospective cohort study
Authors' conclusion
The decline of BMI after surgery was accompanied by a decrease in BMD, fat and LST content, with different proportions of decrease. Our findings indicate that QCT can serve as a supplementary method for postoperative follow-up of BMD and body composition in patients undergoing bariatric surgery.
Study context
- Population
- Patients with obesity who underwent bariatric surgery between March 2022 and September 2024
- Participants
- 65 patients
- Outcome
- Changes in bone mineral density (BMD) after bariatric surgery (DXA and quantitative computed tomography (QCT))
Main finding
As reported in the abstract
- Decrease in area BMD (aBMD) of lumbar spine (LS)
- 3.19 (0.09, 6.50) %
- Decrease in aBMD of femoral neck
- 8.35 (4.66, 12.77) %
- Decrease in aBMD of total hip
- 6.78 (3.98, 10.43) %
- Decrease in volumetric BMD (vBMD) of LS
- 1.57% ± 8.83%
- ΔvBMD smaller than ΔaBMD-LS
- p < 0.05
Observational data: associations, not effects.
Further findings
Body composition
- BMI, whole-body and trunk fat tissue, and lean soft tissue (LST) all decreased significantly
- P < 0.05
- Reduction rate of visceral adipose tissue significantly higher than subcutaneous adipose tissue
- P < 0.05
Correlations with weight loss
- Weak positive correlation between ΔBMI and ΔaBMD-LS
- r = 0.254, p < 0.05
- ΔBMI positively correlated with changes in various body compositions
- P < 0.05
Original publication
Characteristics of changes in bone mineral density and body composition in obesity patients after metabolic and bariatric surgery: A prospective cohort study. Diabetes Obes Metab. Published 25 June 2025. doi:10.
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