Real‐world insights into incretin‐based therapy: Associations between changes in taste perception and appetite regulation in individuals with obesity and overweight: A cross‐sectional study
Authors' conclusion
Self-reported changes in taste perception during GLP-1 or dual GIP/GLP-1 RAS therapy were associated with favourable appetite-related outcomes, suggesting a potential mechanism contributing to treatment response.
Study context
- Population
- Adults with obesity and overweight treated with GLP-1 RA or dual GIP/GLP-1 RA in real-world conditions; 69.6% female, median age 39 (IQR 33–47)
- Participants
- 411 adults
- Exposure
- Self-reported taste perception changes and appetite-related outcomes during GLP-1 RA or dual GIP/GLP-1 RA therapy
- Wegovy®n = 217
- Ozempic®n = 148
- Mounjaro®n = 46
- Outcome
- Associations between self-reported taste changes and satiety, appetite and craving
Methodological detailsonline survey, real-world
- Online survey
- Real-world
Main finding
As reported in the abstract
Associations of taste changes with appetite-related outcomes
- Increased sweet taste perception and increased satiety, AOR
- 2.02 (1.15-4.57) (95% CI)
- Increased sweet taste perception and decreased appetite, AOR
- 1.67 (1.04-3.25) (95% CI)
- Increased sweet taste perception and decreased craving, AOR
- 1.85 (1.05-3.29) (95% CI)
- Increased salty taste perception and increased satiety, AOR
- 2.17 (1.16-5.17) (95% CI)
- Increased sweet taste perception reported
- 21.3%
- Increased salty taste perception reported
- 22.6%
Observational data: associations, not effects.
Further findings
Baseline BMI
Reduced appetite reported
Increased satiety reported
| Outcome | Wegovy® | Ozempic® | Mounjaro® |
|---|---|---|---|
| BMI reduction, adjusted for baseline BMI, treatment duration, dose, age and sex | 17.6% (CI 15.7–19.5) | 17.4% (CI 15.0–19.8) | 15.5% (CI 8.8–22.2) |
- Reduced appetite reported — All participants
- 58.4%
- Increased satiety reported — All participants
- 63.5%
Original publication
Real‐world insights into incretin‐based therapy: Associations between changes in taste perception and appetite regulation in individuals with obesity and overweight: A cross‐sectional study. Diabetes Obes Metab. Published 24 June 2025. doi:10.
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