Characteristics Associated With Elevated Time Below Range in Elderly Patients With Type 1 Diabetes Using an Automated Insulin Delivery System
Authors' conclusion
In elderly patients treated with AID systems with good functional status, lower lean mass, lower grip strength, and lower visceral fat percentage were associated with TBR greater than 1%, regardless of the device used. A similar finding along was found with CGM indicators such as higher HbA1c levels, lower TIR, higher TAR, and higher CV. Geriatric assessment is crucial for personalizing patient management.
Study context
- Population
- Patients >60 years with T1D using SAPT-PLGM, hybrid closed-loop (HCL) or advanced hybrid closed-loop (AHCL) for more than three months
- Participants
- 59 patients
- Exposure
- Elevated time below range (TBR) <70 mg/dL vs not elevated
- Outcome
- Characteristics (geriatric assessment, body composition) associated with achieving TBR <70 mg/dL goals
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
Characteristics associated with elevated TBR <70 mg/dL (>1%)
- Elevated TBR <70 mg/dL (>1%) associated with higher HbA1c, lower time in range (TIR), elevated time above range (TAR) and high glycemic variability
- Greater muscle mass, grip strength and visceral fat associated with lower TBR <70 mg/dL
- These factors were independent of the type of technology used
Observational data: associations, not effects.
Further findings
Glycaemic profile of the cohort
- HbA1c
- 7.5 ± 0.6%
- TIR
- 77.8 ± 9.9%
- TBR <70 mg/dL
- 2.2 ± 2.3%
- TBR <54 mg/dL
- 0.4 ± 0.81%
TIR by technology
- TIR higher with AHCL vs SAPT-PLGM and HCL
Original publication
Characteristics Associated With Elevated Time Below Range in Elderly Patients With Type 1 Diabetes Using an Automated Insulin Delivery System. J Diabetes Sci Technol. Published 20 March 2024. doi:10.
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