Associations between daily step count classifications and continuous glucose monitoring metrics in adults with type 1 diabetes: analysis of the Type 1 Diabetes Exercise Initiative (T1DEXI) cohort
Authors' conclusion
Our results suggest that, compared with days with low step counts, days with higher step counts are associated with slight increases in both TIR and TBR, along with small reductions in total daily insulin requirements, in adults living with type 1 diabetes.
Study context
- Population
- Adults with T1D with available continuous glucose monitoring (CGM) and step count data; mean±SD age 37±14 years; HbA1c 48.8±8.1 mmol/mol [6.6±0.7%]; 73% female; 45% HCL, 38% standard insulin pump, 17% MDI
- Participants
- 464 adults
- Exposure
- Daily step count exceeding vs meeting vs below the step count goal
- Outcome
- CGM metrics incl. TIR (3.9-10.0 mmol/l), TBR (<3.9 mmol/l) and TAR (>10.0 mmol/l)
- Follow-up
- 4 week period
Methodological detailsanalysis of the T1DEXI cohort, 4 week free-living observational study, between- and within-participant analyses
- Analysis of the T1DEXI cohort
- 4 week free-living observational study
- Between- and within-participant analyses
Main finding
As reported in the abstract
P > 0.05
Observational data: associations, not effects.
Further findings
TIR (3.9-10.0 mmol/l), within-participant comparison by day · 4 week period — Exceeding vs Below · higher on days goal exceeded · within-participant comparisons
P < 0.001
Total daily insulin dose, within-participant comparison by day · 4 week period — Exceeding vs Below · lower on days goal exceeded · within-participant comparisons
P < 0.001
| Outcome | Difference in means (%) | P value |
|---|---|---|
| TIR (3.9-10.0 mmol/l), within-participant comparison by day · 4 week periodMeeting vs Below · higher on days goal met · within-participant comparisons | P < 0.001 | |
| TBR (<3.9 mmol/l), within-participant comparison by day · 4 week periodBelow vs Exceeding · TBR higher on days goal exceeded · within-participant comparisons | −0.4 | P = 0.001 |
| Total daily insulin dose, within-participant comparison by day · 4 week periodMeeting vs Below · lower on days goal met · within-participant comparisons | P < 0.001 |
CGM metrics, subgroup baseline HbA1c ≥53 mmol/mol (≥7.0%)
- Step count had a larger effect on CGM-based metrics in participants with baseline HbA1c ≥53 mmol/mol (≥7.0%)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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