Impact of Age at Diagnosis and Insulin Delivery Modality on Free-Living Glycemia in Type 1 Diabetes During Periods Associated with Dysglycemia: A Retrospective Analysis of the Type 1 Diabetes Exercise Initiative Study
Primary result · TIR (70-180 mg/dL), overallResult — go to the resultDifference 12.3 % 95% CI 4.9%–19.8%Authors' conclusion
In addition to insulin modality, age at type 1 diabetes diagnosis independently impacts on glycemia in adults and should be factored into personalized care planning.
Study context
- Population
- People with T1D duration >5 years in the T1DEXI Study; 4 weeks' free-living data
- Participants
- 423 people
- Comparison
- Age at diagnosis groups and insulin delivery modality
- Primary endpoint
- Percentage time in different glycemic states over 24 h, during sleep/exercise and 2 h post-prandially
- Follow-up
- 4 weeks
Methodological detailsretrospective analysis, mixed-effects linear regression
- Retrospective analysis
- Mixed-effects linear regression
Primary result
TIR (70-180 mg/dL), overall
Difference
12.3 %
95% CI 4.9%–19.8%
P = 0.0002
By group
AgeDx>30vs AgeDx<7
difference 12.3 % (95% CI 4.9%–19.8%); P = 0.0002
As reported in the abstract
Further findings
| Outcome | Difference (%) (95% CI) | P value | |
|---|---|---|---|
| TIR during exerciseAgeDx>30vs AgeDx<7Higher TIR with AgeDx>30 | 13.7 (5.3%–22.0%) | P = 0.0002 | |
| TIR during exerciseAgeDx13-30vs AgeDx<7More TIR with AgeDx13-30 | 8.3 (1.9%–14.7%) | P = 0.0050 | |
| TIR during sleepAgeDx>30vs AgeDx<7Higher TIR with AgeDx>30 | 11.0 (3.5%–17.0%) | P = 0.0043 | |
| TIR post-prandiallyAgeDx>30vs AgeDx<7Higher TIR with AgeDx>30 | 14.9 (5.9–23.9%) | P = 0.0001 | |
| −100102030Difference, % (linear scale) |
| Outcome | P value |
|---|---|
| TIR by insulin delivery modalityHCL vs CSII alone · more TIR with HCL | P < 0.001 |
| TIR by insulin delivery modalityHCL vs MDI · more TIR with HCL | P < 0.001 |
Original publication
Impact of Age at Diagnosis and Insulin Delivery Modality on Free-Living Glycemia in Type 1 Diabetes During Periods Associated with Dysglycemia: A Retrospective Analysis of the Type 1 Diabetes Exercise Initiative Study. Diabetes Technol Ther. Published 19 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →