Cerebral Cortical Thickness Morphometry and Neurocognitive Correlations in Adolescents With Congenital Hypothyroidism
Authors' conclusion
There was a trend toward morphometric alterations in the cerebral cortex of adolescents with CH compared with healthy controls. The correlations between CT and variables of neurocognitive prognosis emphasize the influence of hypothyroidism on cortical development. Socioeconomic status exerts a limiting factor on cognitive outcome.
Study context
- Population
- Adolescents with CH detected by the neonatal screening (NS) Program (Paraná, Brazil); 29 girls among patients
- Participants
- 41 vs 20
- Exposure
- Adolescents with CH vs healthy controls
- CHn = 41
- Controlsn = 20reference
- Outcome
- Cerebral cortical thickness (CT) in 33 brain areas of each hemisphere on MRI, and its correlation with FSIQ, age at start of treatment, pretreatment thyroxine and maternal schooling
Methodological detailscontrolled, MRI morphometry, psychometric evaluation
- Controlled
- MRI morphometry
- Psychometric evaluation
Main finding
As reported in the abstract
Cortical thickness
- No significant difference in cortical thickness (CT) between patients and controls
- Trend toward thinning in right lateral orbitofrontal cortex among patients and in right postcentral gyrus cortex among controls
- CT correlated significantly with Full-scale Intelligence Quotient (FSIQ) and with age at start of treatment in 1 area
- CT correlated with hypothyroidism severity in 5 brain areas
Observational data: associations, not effects.
Further findings
| Outcome | CH |
|---|---|
| Cognitive level in patients | 44.7% |
| Intellectual deficiency | 13.2% |
- Cognitive level in patients — Cognitive level within average
- 44.7%
- Cognitive level in patients — Intellectual deficiency
- 13.2%
Maternal schooling
- Maternal schooling did not correlate with CT but correlated significantly with FSIQ
Original publication
Cerebral Cortical Thickness Morphometry and Neurocognitive Correlations in Adolescents With Congenital Hypothyroidism. J Clin Endocrinol Metab. Published 4 July 2023. doi:10.
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