Clinical course of peripheral precocious puberty in girls due to autonomous ovarian cysts
Authors' conclusion
Most ovarian cysts in PPP spontaneously disappear. However, this could be one of the findings of MAS. Some girls progress from PPP to CPP. Therefore, follow-up is necessary for ovarian cysts in patients with PPP. The recurrence of ovarian cysts may occur when spontaneous regression is prolonged.
Study context
- Population
- Girls with peripheral precocious puberty (PPP) due to ovarian cysts, with or without McCune-Albright syndrome (MAS), diagnosed January 2003–May 2022
- Participants
- 12 participants
- Outcome
- Clinical course of ovarian cysts in PPP
Main finding
As reported in the abstract
- Episodes of ovarian cysts
- 18
- Median ovarian cyst size
- 27.5 mm
- Girls diagnosed with MAS
- 5
- Median time to spontaneous regression
- 6 months
- Progressed to central precocious puberty (CPP)
- 4 out of 12 girls
- Recurrence of ovarian cysts among girls progressing to CPP
- 3
Observational data: associations, not effects.
Further findings
- Difference in peak luteinizing hormone (LH) in gonadotropin-releasing hormone (GnRH) stimulation test and period to cyst regression between non-recurrent and recurrent groups
Original publication
Clinical course of peripheral precocious puberty in girls due to autonomous ovarian cysts. Clin Endocrinol (Oxf). Published 29 June 2023. doi:10.
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