Cardiovascular status in chronic hypoparathyroidism: a systematic cross-sectional assessment in 168 patients
Authors' conclusion
Patients with hypoPT exhibit a higher prevalence of QTc interval prolongation despite established therapy and an increased incidence of hypertension. Conversely, echocardiography revealed lower left ventricular mass and less frequent left ventricular hypertrophy in hypoPT, but higher prevalence of valve stenosis. Regular monitoring of hypertension, QTc interval prolongation, and valve stenosis is recommended to reduce the risk of cardiovascular diseases.
Study context
- Population
- Patients with chronic hypoparathyroidism vs matched controls from German population-based cohorts (SHIP-TREND, Stages A-B (STAAB))
- Participants
- 168 hypoparathyroidism (hypoPT) patients
- Exposure
- Chronic hypoPT vs matched population controls
- HypoPTn = 168
- Outcome
- Cardiovascular parameters (BP, ECG, echocardiography)
Methodological details1:3 propensity score matching, matched controls from SHIP-TREND and STAAB cohorts
- 1:3 propensity score matching
- Matched controls from SHIP-TREND and STAAB cohorts
Main finding
As reported in the abstract
- HypoPT
- systolic BP 128 vs 125 mm Hg; P = 0.02
- HypoPT
- diastolic BP 83 vs 77 mm Hg; P < 0.01
- HypoPT
- QTc interval 438 vs 420 ms; P < 0.01
- HypoPT
- QTc interval prolongation 24% vs 6%; P < 0.01
- HypoPT
- left ventricular mass index 28 vs 43 g/m2.7; P < 0.01
- HypoPT
- left ventricular hypertrophy 7%% vs 41%; P < 0.01
- HypoPT
- mitral valve stenosis 20 vs 0%; P < 0.01
- HypoPT
- aortic valve stenosis 7 vs 2%; P < 0.01
- Comparable left ventricular ejection fraction
- P = 0.48
Observational data: associations, not effects.
Original publication
Cardiovascular status in chronic hypoparathyroidism: a systematic cross-sectional assessment in 168 patients. Eur J Endocrinol. Published 2 April 2025. doi:10.
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