Increased Risk of Cardiovascular Diseases in Patients With Chronic Hypoparathyroidism in Sweden
Authors' conclusion
The risk of cardiovascular diseases was increased in patients with chronic hypoPT, particularly among women. These findings highlight the need for close monitoring and preventive management of cardiovascular risk factors, especially in women.
Study context
- Population
- Patients with chronic hypoparathyroidism and matched controls, Swedish national registries, 1997–2018matched cohort
- Participants
- 1,982 vs 19,499
- Exposure
- Chronic hypoparathyroidism (hypoPT) vs matched controls
- Chronic hypoPTn = 1,982
- Controlsn = 19,499reference
- Outcome
- Cardiovascular outcomes: acute MI, AF/flutter, HF, valvular heart disease, peripheral artery disease, stroke/TIA
Methodological detailsmatched controls, national registries
- Matched controls
- National registries
Main finding
As reported in the abstract
Cardiovascular outcomes, adjusted for cardiovascular risk factors
Chronic hypoPT vs ControlsHazard ratio (95% CI)
Valvular heart disease
2.08(1.67–2.60)
Peripheral artery disease
1.78(1.41–2.26)
HF
1.66(1.44–1.90)
AF/flutter
1.58(1.38–1.81)
Acute MI
1.31(1.05–1.64)
Fatal CVD
1.59(1.40–1.80)
Observational data: associations, not effects.
Further findings
Surgical vs nonsurgical chronic hypoPT
- Cardiovascular outcomes did not differ between surgical and nonsurgical chronic hypoPT
Females
- Females with hypoPT had significantly increased risk of valvular heart disease, peripheral artery disease, HF, AF, MI and fatal CVD vs female controls
Males
- No differences in any cardiovascular outcomes between males with hypoPT and male controls
Original publication
Increased Risk of Cardiovascular Diseases in Patients With Chronic Hypoparathyroidism in Sweden. J Clin Endocrinol Metab. Published 28 April 2025. doi:10.
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