Cardiovascular diseases consequences of type 1, type 2 diabetes mellitus and glycemic traits: A Mendelian randomization study
Authors' conclusion
T1D and T2D exhibit different genetic predisposition to CVDs. BMI, LDL, and HDL play intermediary roles in connecting TID and T2D to specific types of CVDs, providing insights into the potential underlying pathways and mechanisms involved in these relationships. Strategies aimed at achieving sustained reductions in HbA1c levels may offer potential for reducing the risk of various CVDs.
Study context
- Population
- Genetic instruments from published genome-wide association studies; 12 common cardiovascular diseases (CVDs) from FinnGen and UK Biobank, stroke subtypes from GIGASTROKE and MEGASTROKE Consortium
- Comparison
- Genetic predisposition to T1D, T2D, fasting insulin, fasting glucose and HbA1c vs CVDs
- Outcome
- CVDs
Methodological details2-Sample Mendelian randomization (MR)
- 2-Sample MR
Main finding
As reported in the abstract
- Genetically predicted higher HbA1c associated with eight CVDs
- 8
Original publication
Cardiovascular diseases consequences of type 1, type 2 diabetes mellitus and glycemic traits: A Mendelian randomization study. Diabetes Res Clin Pract. Published 13 January 2024. doi:10.
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