Non‐alcoholic fatty liver disease and complications in type 1 and type 2 diabetes: A Mendelian randomization study
Authors' conclusion
This study supports a causal effect of genetically driven chronic serum alanine aminotransferase-associated NAFLD on early-stage kidney disease in T1D and a suggestive causal effect on ketoacidosis in T1D. However, MR studies did not provide enough evidence to suggest that NAFLD independently increases the risk of retinopathy in T1D and of ketoacidosis, nephropathy and retinopathy in T2D.
Study context
- Population
- T1D and T2D; genetic instruments from a recent genome-wide association study
- Comparison
- Genetically instrumented non-alcoholic fatty liver disease (NAFLD) and diabetes complications
- Outcome
- Diabetes-related complications: diabetic ketoacidosis, nephropathy and retinopathy in T1D and T2D
Methodological detailstwo-sample, four complementary Mendelian randomization (MR) methods
- Two-sample
- Four complementary MR methods
Main finding
As reported in the abstract
Ketoacidosis in T1D: suggestive causal association, OR
1.574
95% CI 1.076, 2.302; P = .019; FDR = 0.096
Early-stage kidney disease in T1D: significant causal association, OR
1.249
95% CI 1.089, 1.432; P = 1.457 × 10–3, FDR = 0.015
Further findings
Sensitivity analysis
- Low heterogeneity, low pleiotropy and high reliability of the causal estimates
Original publication
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