Association of type 1 diabetes and age at diagnosis of type 2 diabetes with brain volume and risk of dementia in the UK Biobank: A prospective cohort study of community‐dwelling participants
Authors' conclusion
Individuals with T1D or T2D diagnosed at younger age are at larger excessive risk of brain volume reduction and dementia.
Study context
- Population
- Community-dwelling UK Biobank participants with diabetes and randomly selected controls; brain volume analysis 1376 with diabetes and 2752 controls; dementia analysis 25,141 with diabetes and 50,282 controls
- Exposure
- T1D and T2D by age at diagnosis vs controls without diabetes
- Outcome
- Brain volume (MRI) and incident dementia (hospital inpatient records and mortality register)
- Follow-up
- Median 11.9 years
Methodological detailsUK Biobank, randomly selected controls
- UK Biobank
- Randomly selected controls
Main finding
As reported in the abstract
Incident dementia
Each group vs controlsHazard ratio (95% CI)
T2D diagnosed <50 yearsmultivariable analysis; largest HR among T2D age-at-diagnosis categories
2.03(1.53–2.69)
T1D
2.08(1.40–3.09)
- New dementia cases
- 2035
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| Brain volume (adjusted for HbA1c and other covariates)T2D diagnosed <50 years vs Controls | β (total brain volume) −14.56 ml (95% CI −24.67 to −4.44) |
| Brain volume (adjusted for HbA1c and other covariates)T2D diagnosed <50 years vs Controls | β (grey matter volume) −6.47 ml (95% CI −12.75 to −0.20) |
| Brain volume (adjusted for HbA1c and other covariates)T2D diagnosed <50 years vs Controls | β (white matter volume) −8.08 ml (95% CI −14.66 to −1.51) |
| Brain volume (adjusted for HbA1c and other covariates)T1D vs Controls | β (total brain volume) −62.86 ml (95% CI −93.71,−32.01) |
| Brain volume (adjusted for HbA1c and other covariates)T1D vs Controls | β (grey matter volume) −34.27 ml (95% CI −53.72 to −14.83) |
| Brain volume (adjusted for HbA1c and other covariates)T1D vs Controls | β (white matter volume) −28.59 ml (95% CI −47.65 to −9.52) |
Brain volume (adjusted for HbA1c and other covariates)
- T2D diagnosed at younger age associated with larger brain volume reductions; after adjustment only T2D <50 years associated with smaller volumes
Original publication
Association of type 1 diabetes and age at diagnosis of type 2 diabetes with brain volume and risk of dementia in the UK Biobank: A prospective cohort study of community‐dwelling participants. Diabet Med. Published 31 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →