Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes
Authors' conclusion
CAN was associated with increased glycemic variability with less time in euglycemia attributed to a greater time in hyperglycemia but not hypoglycemia.
Study context
- Population
- Patients with T1D or T2D (aged 40.70 ± 13.73 years, diabetes duration 14.43 ± 7.35 years, HbA1c 8.85 ± 1.70%) undergoing continuous glucose monitoring (CGM)20 T1D, 20 T2D
- Participants
- 40 patients
- Exposure
- Diabetes with cardiac autonomic neuropathy (CAN) vs without CAN
- CANn = 23
- Outcome
- Measures of glucose variability (GV) on CGM in relation to CAN
Main finding
As reported in the abstract
Coefficient of variation (CV)
CAN
31.26
mean · ± 11.87
No CAN
40.33
mean · ± 11.03
P = 0.018
- CAN prevalence
- 23 (57.5%)
Observational data: associations, not effects.
Further findings
| Outcome | CAN | No CAN | P value |
|---|---|---|---|
| CONGAHigher with CAN | mean 8.42 ± 2.58 | mean 6.68 ± 1.88 | P = 0.024 |
| LBGILower with CAN · median | 1.60 (range 0.20–3.50) | 4.90 (range 3.20–7.40) | P = 0.010 |
| % GRADEEuglycemiaLower with CAN | mean 3.30 ± 2.78 | mean 5.69 ± 3.09 | P = 0.017 |
| GRADEHypoglycemiaLower with CAN | 0.3 (range 0–3.80) | 1.8 (range 0.9–6.5) | P = 0.036 |
| % GRADEHyperglycemiaHigher with CAN · median | 95.45 (range 93–98) | 91.6 (range 82.8–95.1) | P = 0.013 |
- % time in hypoglycemia · reported lower with CAN
- P = 0.008
Original publication
Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes. Diabetes Res Clin Pract. Published 9 May 2023. doi:10.
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