Can cardiovascular health and its modifiable healthy lifestyle offset the increased risk of all-cause and cardiovascular deaths associated with insulin resistance?
Authors' conclusion
In this cohort study, improving cardiovascular health and modifiable health behaviors significantly reduced the risk of insulin resistance-related all-cause and cardiovascular deaths. Maintaining cardiovascular health at moderate or high levels (LE8 ≥ 50) could offset the increased risks caused by insulin resistance.
Study context
- Population
- Healthy participants from the 2005–2018 NHANES programme
- Participants
- 14,172 participants
- Exposure
- Insulin resistance (IR) and cardiovascular health (CVH) and their joint categories
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Mean 7.6 years
Methodological detailsNHANES 2005-2018, weighted multifactor Cox regression, restricted cubic spline
- NHANES 2005-2018
- Weighted multifactor Cox regression
- Restricted cubic spline
Main finding
As reported in the abstract
Deaths
1534
Cardiovascular deaths
382
Observational data: associations, not effects.
Original publication
Can cardiovascular health and its modifiable healthy lifestyle offset the increased risk of all-cause and cardiovascular deaths associated with insulin resistance? Cardiovasc Diabetol. Published 10 March 2025. doi:10.
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