Association of triglyceride-glucose-related indices with all-cause and cause-specific mortality in individuals with prediabetesss
Authors' conclusion
Elevated TyG and TyG-WC levels were significantly associated with increased cancer mortality risk, while TyG-WHtR showed stronger associations with all-cause and cause-specific mortality in individuals with prediabetes. These indices could serve as surrogate biomarkers for follow-up and clinical management of individuals with prediabetes.
Study context
- Population
- Individuals with prediabetes, NHANES 1999–2018; mortality followed to December 31, 2019
- Participants
- 9,574 individuals
- Exposure
- Quartiles of triglyceride-glucose (TyG)-related indices
- Outcome
- All-cause and cause-specific (CVD, cancer) mortality
- Follow-up
- As of December 31, 2019
Methodological detailsNHANES 1999–2018, Kaplan-Meier curves, Cox regression, restricted cubic splines, subgroup and sensitivity analyses
- NHANES 1999–2018
- Kaplan-Meier curves
- Cox regression
- Restricted cubic splines
- Subgroup and sensitivity analyses
Main finding
As reported in the abstract
TyG index Q4 and cancer mortality (multivariate Cox), HR
1.957
95% CI 1.126–3.402P = 0.017
High quartiles of TyG-waist circumference (TyG-WC) and cancer mortality, HR
2.397
95% CI 1.062–5.409P = 0.035
Observational data: associations, not effects.
Further findings
Nonlinearity (restricted cubic splines (RCS)) of TyG-WC and TyG-waist-to-height ratio (TyG-WHtR) with cancer mortality
- TyG-WC and TyG-WHtR nonlinearly correlated with cancer mortality (P for nonlinear = 0.028 and 0.006)
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →