Association between triglyceride-glucose related indices and all-cause and cardiovascular mortality among the population with cardiovascular-kidney-metabolic syndrome stage 0–3: a cohort study
Authors' conclusion
Our study emphasizes the association between TyG and TyG-related indices and mortality in individuals with CKM syndrome stages 0-3. Individuals with CKM syndrome stages 1 and 3 should be more vigilant to abnormal alterations in TyG-related indices.
Study context
- Population
- Population with cardiovascular-Kidney-Metabolic (CKM) syndrome stage 0–3, National Health and Nutrition Examination Survey (NHANES) 2009–2018
- Participants
- 6,383 participants
- Exposure
- Triglyceride-glucose (TyG) and TyG-related indices (TyG-waist-to-height ratio (TyG-WHtR), TyG-waist circumference (TyG-WC), TyG-body mass index (TyG-BMI)) in relation to all-cause and cardiovascular mortality
- Outcome
- All-cause and cardiovascular mortality
Methodological detailsNHANES 2009-2018, survey-weighted
- NHANES 2009-2018
- Survey-weighted
Main finding
As reported in the abstract
TyG-WC index and all-cause mortality, HR
1.50 (1.18-1.92) (95% CI)
TyG-WHtR index and all-cause mortality, HR
1.45 (1.13-1.85) (95% CI)
TyG-WHtR index and cardiovascular mortality, HR
1.85 (1.19-2.86) (95% CI)
TyG-WC index and cardiovascular mortality, HR
1.83 (1.21-2.78) (95% CI)
Observational data: associations, not effects.
Further findings
Nonlinear relationship: L-shaped association of TyG-WHtR and TyG-BMI with all-cause mortality
- L-shaped association between TyG-WHtR, TyG-BMI and all-cause mortality
- both P for log-likelihood ratio < 0.05
Subgroups by CKM syndrome stage: all-cause mortality
- TyG-WHtR, TyG-WC and TyG-BMI more pronounced correlation with all-cause mortality in CKM syndrome stages 1 and 3
- P < 0.05, P for interaction < 0.05
Original publication
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