Comparison of triglyceride glucose index and modified triglyceride glucose indices in predicting cardiovascular diseases incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study
Authors' conclusion
The TyG index and all the modified TyG indices were independent predictors of CVD incidence among people with CKM syndrome stages 0-3. It was found that modified indices had better predictive performance, especially TyG combined with waist circumference or waist-to-height ratio.
Study context
- Population
- Participants with cardiovascular-kidney-metabolic (CKM) syndrome stages 0–3, China Health and Retirement Longitudinal Study
- Participants
- 7,364 participants
- Exposure
- Triglyceride glucose (TyG) index vs modified TyG indices for predicting cardiovascular diseases (CVD) incidence
- Outcome
- CVD incidence
- Follow-up
- Nine years
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Prediction of CVD incidence (time-dependent Harrell's C-index)
| Group | C-index | P |
|---|---|---|
| TyG | 0.611 | p < 0.001 |
| TyG-WC | 0.621 | p < 0.001 |
| TyG-WHtR | 0.621 | p < 0.001 |
| TyG-BMI | 0.616 | p < 0.001 |
C-index
TyG0.611
TyG-WC0.621
TyG-WHtR0.621
TyG-BMI0.616
P
TyGp < 0.001
TyG-WCp < 0.001
TyG-WHtRp < 0.001
TyG-BMIp < 0.001
Observational data: associations, not effects.
Further findings
CVD incidence · nine years
- CVD incidence
- 20.55%
Dose-response (RCS regression)
- All indicators had linear relationships with CVD incidence; for TyG-WC and TyG-WHtR these persisted in CKM stages 1, 2 and 3
Original publication
Comparison of triglyceride glucose index and modified triglyceride glucose indices in predicting cardiovascular diseases incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study. Cardiovasc Diabetol. Published 28 February 2025. doi:10.
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