Associations of triglyceride glucose-body mass index with short-term mortality in critically ill patients with ischemic stroke
Authors' conclusion
Elevated TyG-BMI is significantly associated with an increased risk of short-term all-cause mortality in patients with critically ill IS in the United States. This result provides compelling evidence to address the existing discrepancies in this research domain, indicating that the TyG-BMI could serve as a straightforward and efficient biomarker for identifying critically ill IS patients at high risk of mortality.
Study context
- Population
- Critically ill patients with ischemic stroke, eICU database (United States); mean age 68.41 ± 14.16 years, 47.50% male
- Participants
- 1,362 patients
- Exposure
- High vs lower triglyceride glucose-body mass index (TyG-BMI)
- Outcome
- 28-day mortality (hospital and ICU)
- Follow-up
- 28 days
Methodological detailseICU database, multivariate Cox regression, restricted cubic splines
- eICU database
- Multivariate Cox regression
- Restricted cubic splines
Main finding
As reported in the abstract
28-day hospital mortality, high TyG-BMI group (multivariate Cox)
HR = 1.734
P = 0.032
28-day ICU mortality, high TyG-BMI group (multivariate Cox)
HR = 2.337
p = 0.048
Observational data: associations, not effects.
Further findings
Nonlinear association of TyG-BMI with 28-day hospital mortality (restricted cubic splines (RCS))
- Nonlinear positive correlation; inflection point TyG-BMI
- 380.37
- Below inflection point, per 1-SD (≈25.5 units) increase
- HR = 1.373, P = 0.015
- Above 380.376, per 1-SD increase
- HR = 0.121, P = 0.057
- Log-likelihood ratio test
- P = 0.004
Association of TyG-BMI with 28-day ICU mortality (RCS)
- Significant positive linear correlation
Original publication
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